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Which is the most recently discovered antimicrobial agent?
Most recently discovered antimicrobial agents are modified natural compounds and this modification is done through chemical mode [1], for example, b-lactams (penicillins), carbapenems, or cephalosporin. Pure natural products, such as aminoglycosides, and other entirely synthetic antibiotics, for example, sulfonamides, are also frequently used.
Why are antibacterial agents important to infectious diseases?
Antibacterial agents are the most important in fighting infectious diseases. But, with their wide use as well as abuse, the appearance of bacterial resistance toward antibacterial agents has become a major problem for today's pharmaceutical industry.
Why are biofilms a defense mechanism against antimicrobial agents?
The ability of bacteria to form biofilms constitutes one of the possible defense mechanisms from antimicrobial agents. Biofilms formation on medical devices, as indwelling catheters, and in infected wounds leads to chronic and life-threatening infections that are recalcitrant to antibiotics treatment.
Which is antibacterial agent has the best inhibitory activity?
Moderate antibacterial activity was observed with the best inhibitory activity against S. aureus and E. faecalis (MIC: 0.3 mg/mL). However, storage of the plant extract (6 week duration) resulted in a sharp decline (MIC: 2.3 mg/mL) in antibacterial activity ( Eloff, 1999 ).
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